Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
Identifieur interne : 002E67 ( Main/Exploration ); précédent : 002E66; suivant : 002E68Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
Auteurs : Mahyar Etminan [Canada] ; Sudeep Gill [Canada] ; Ali Samii [États-Unis]Source :
- BMJ [ 0959-8138 ] ; 2003-07-17.
Abstract
Objectives To quantify the risk of Alzheimer's disease in users of all non-steroidal anti-inflammatory drugs (NSAIDs) and users of aspirin and to determine any influence of duration of use. Design Systematic review and meta-analysis of observational studies published between 1966 and October 2002 that examined the role of NSAID use in preventing Alzheimer's disease. Studies identified through Medline, Embase, International Pharmaceutical Abstracts, and the Cochrane Library. Results Nine studies looked at all NSAIDs in adults aged > 55 years. Six were cohort studies (total of 13 211 participants), and three were case-control studies (1443 participants). The pooled relative risk of Alzheimer's disease among users of NSAIDs was 0.72 (95% confidence interval 0.56 to 0.94). The risk was 0.95 (0.70 to 1.29) among short term users (< 1 month) and 0.83 (0.65 to 1.06) and 0.27 (0.13 to 0.58) among intermediate term (mostly < 24 months) and long term (mostly > 24 months) users, respectively. The pooled relative risk in the eight studies of aspirin users was 0.87 (0.70 to 1.07). Conclusions NSAIDs offer some protection against the development of Alzheimer's disease. The appropriate dosage and duration of drug use and the ratios of risk to benefit are still unclear.
Url:
DOI: 10.1136/bmj.327.7407.128
Affiliations:
- Canada, États-Unis
- Ontario, Washington (État)
- Seattle, Toronto
- Université de Toronto, Université de Washington
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002580
- to stream Istex, to step Curation: 002580
- to stream Istex, to step Checkpoint: 000E70
- to stream Main, to step Merge: 003265
- to stream Main, to step Curation: 002E67
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies</title><author><name sortKey="Etminan, Mahyar" sort="Etminan, Mahyar" uniqKey="Etminan M" first="Mahyar" last="Etminan">Mahyar Etminan</name></author><author><name sortKey="Gill, Sudeep" sort="Gill, Sudeep" uniqKey="Gill S" first="Sudeep" last="Gill">Sudeep Gill</name></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B610BC7CCDA1768A779518ADD4BD671A39F8D28C</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1136/bmj.327.7407.128</idno><idno type="url">https://api-v5.istex.fr/document/B610BC7CCDA1768A779518ADD4BD671A39F8D28C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002580</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002580</idno><idno type="wicri:Area/Istex/Curation">002580</idno><idno type="wicri:Area/Istex/Checkpoint">000E70</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000E70</idno><idno type="wicri:doubleKey">0959-8138:2003:Etminan M:effect:of:non</idno><idno type="wicri:Area/Main/Merge">003265</idno><idno type="wicri:Area/Main/Curation">002E67</idno><idno type="wicri:Area/Main/Exploration">002E67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies</title><author><name sortKey="Etminan, Mahyar" sort="Etminan, Mahyar" uniqKey="Etminan M" first="Mahyar" last="Etminan">Mahyar Etminan</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Gill, Sudeep" sort="Gill, Sudeep" uniqKey="Gill S" first="Sudeep" last="Gill">Sudeep Gill</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Department of Health Policy, Management and Evaluation, University of Toronto</wicri:regionArea><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">BMJ</title><title level="j" type="abbrev">BMJ</title><idno type="ISSN">0959-8138</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="2003-07-17">2003-07-17</date><biblScope unit="volume">327</biblScope><biblScope unit="issue">7407</biblScope><biblScope unit="page" from="128">128</biblScope></imprint><idno type="ISSN">0959-8138</idno></series><idno type="istex">B610BC7CCDA1768A779518ADD4BD671A39F8D28C</idno><idno type="DOI">10.1136/bmj.327.7407.128</idno><idno type="href">bmj-327-128.pdf</idno><idno type="ArticleID">bmj.327.7407.128</idno><idno type="PMID">12869452</idno><idno type="local">bmj;327/7407/128</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-8138</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives To quantify the risk of Alzheimer's disease in users of all non-steroidal anti-inflammatory drugs (NSAIDs) and users of aspirin and to determine any influence of duration of use. Design Systematic review and meta-analysis of observational studies published between 1966 and October 2002 that examined the role of NSAID use in preventing Alzheimer's disease. Studies identified through Medline, Embase, International Pharmaceutical Abstracts, and the Cochrane Library. Results Nine studies looked at all NSAIDs in adults aged > 55 years. Six were cohort studies (total of 13 211 participants), and three were case-control studies (1443 participants). The pooled relative risk of Alzheimer's disease among users of NSAIDs was 0.72 (95% confidence interval 0.56 to 0.94). The risk was 0.95 (0.70 to 1.29) among short term users (< 1 month) and 0.83 (0.65 to 1.06) and 0.27 (0.13 to 0.58) among intermediate term (mostly < 24 months) and long term (mostly > 24 months) users, respectively. The pooled relative risk in the eight studies of aspirin users was 0.87 (0.70 to 1.07). Conclusions NSAIDs offer some protection against the development of Alzheimer's disease. The appropriate dosage and duration of drug use and the ratios of risk to benefit are still unclear.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Ontario</li><li>Washington (État)</li></region><settlement><li>Seattle</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li><li>Université de Washington</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Etminan, Mahyar" sort="Etminan, Mahyar" uniqKey="Etminan M" first="Mahyar" last="Etminan">Mahyar Etminan</name></noRegion><name sortKey="Gill, Sudeep" sort="Gill, Sudeep" uniqKey="Gill S" first="Sudeep" last="Gill">Sudeep Gill</name></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002E67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B610BC7CCDA1768A779518ADD4BD671A39F8D28C
|texte= Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
}}
| This area was generated with Dilib version V0.6.29. |  |